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The therapeutic potential of curcumin has become increasingly evident over the past several decades

The actual mechanism is likely to occur via two sequential steps with semiquinone (SQ . ) and superoxide (O2 . ) intermediates

Although the recommended dose for adults is 15 mg, recommended dose for elder population ranges from 400 to 800 mg daily [85]

However, despite this, it is clear that the inhibitory action of juglone on ChaC1 is novel, since juglone does not appear to be inhibiting ChaC1 by any of the known and reported mechanisms

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