Simultaneously, ferroptosis may be involved in the progression of cardiac autonomic neuropathy (DCAN) through the P2Y14 receptor (a new member of the metabolic receptor family), while P2Y14 targeting naringin can alleviate DCAN by promoting the NRF2-GPX4 pathway to eliminate ROS and inhibit ferroptosis (117) ( Figure 2 )
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Firstly, our literature search was limited to English and Chinese databases (PubMed, CNKI, etc.), and we acknowledged that this may have excluded relevant studies published in other languages or regional databasespotentially narrowing the scope of evidence synthesized
Guan C, Ji J, Jia C, Guan W, Li X, Jin C, Wang G (2015) A GSHS-like gene from Lycium chinense may be regulated by cadmium-induced endogenous salicylic acid and overexpression of this gene enhances tolerance to cadmium stress in Arabidopsis
M0, macrophage 0