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Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology

doi: 10.1016/j.ifset.2018.10.005 55 LoiraI.MorataA.PalomeroF.GonzlezC.Surez-LepeJ

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Decreased GSH then results in lipid peroxide accumulation and induction of ferroptosis