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Enzymes, pH fluctuations, and the liver's first-pass metabolism can all dramatically reduce the bioavailability of a compound

(PubMed) Desmond MA, Sobiecki JG, Jaworski M, et al

FDA in 2014

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

However, if your body isnt receiving sufficient B12 vitamins, its not unusual to notice drastic changes in your weight