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Neurological Fatigue: By reducing elevated ventricular lactate and supporting efficient mitochondrial ATP production in the brain, NAC helps alleviate the heavy, "weighted" feeling in the head often reported by patients

Clin Biochem.20023516972.

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They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

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