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Farina et al., 2005), monkeys (Rice, 1996) and zebrafish ( Danio rerio ) (Samson et al., 2001)

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Acknowledgements This research was supported in part through a University of Michigan Developmental Research/ GI SPORE (P50 CA130810) Pilot Award

Its key physiological functions include: Nitrogen transport between tissues Acid-base regulation Supporting gluconeogenesis Serving as a precursor to nucleotide bases Boosting the antioxidant glutathione (Cruzat et al., 2018, Nutrients ) Glutamines Role in Muscle Growth and Recovery L-Glutamine plays a powerful role as a signaling molecule in stimulating anabolic pathways such as muscle protein synthesis and cell growth , while inhibiting catabolic pathways including protein degradation and apoptosis (Newsholme et al., 2003, The Journal of Nutrition )