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Puerarin also inhibits the release and transport of glucose and FFAs, acts on the PI3K-Akt and AMPK signaling pathways to reduce glucose and fatty acid synthesis, downregulates the expression of PPAR/, inhibits the expression of TGF-1 and NF-B p65 to exert antifibrotic effects, and improves insulin secretion and sensitivity [139]

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Body-Composition Effects: Fat Loss and Lean Mass Preservation: Research suggests that IGF-1 LR3 supports fat loss and lean mass preservation by influencing body composition