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However, since the signalling pathway is complicated and bidirectional, application of BDNF in neuroprotection in humans remains to be elucidated

Altered biochemical environment such as redox potential, pH, hypoxia, temperature, reactive oxygen species (ROS) and overexpression of proteins/enzymes represent the intrinsic characteristics of affected pathological areas/tissues in the body 5,6,7,8,9,10,11