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The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules)

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Oxidative stress caused by iron overload further induces lipid peroxidation, destroys mitochondrial membrane and function, and causes redox imbalance

Further rodent studies emphasized the gut microbiotas integral role in orchestrating systemic immune responses, indicating that a balanced microbiome conditions the lung milieu for defense by modulating interferon (IFN) signaling pathways

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