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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal toxicology shows wide therapeutic window Injection-site reactions reported anecdotally Known interactions Anticoagulants (theoretical, due to angiogenic activity unstudied) Contraindications Active malignancy (theoretical, due to angiogenic mechanism) Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Placed on FDA Category 2 of the 503A bulks list (September 2023 update), barring compounding pharmacies from preparing it under section 503A

Intraperitoneal or oral administration inhibited bladder cancer cell migration and invasion and reduced the formation of distant metastases, through mechanisms involving cellular metabolic regulation and downregulation of metastasisrelated proteins

Eur J Pharmacol 2005

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