NO-releasing agents, such as JS-K ( O 2 -(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) 123 and PABA/NO ( O 2 -[2,4-dinitro-5-( N -methyl- N -4 carboxyphenylamino)phenyl] 1- N , N -dimethylamino)diazen-1-ium-1,2-diolate) 124 , are able to induce differentiation and cell death in a variety of cancer cells through GSH consumption, DNA synthesis inhibition and inhibition of enzymes involved in the defense against cell damage
juncea GCL shows the locations of these two disulfide bonds (Figure 3B): one disulfide bond (Cys178Cys398) is located at the interface between monomers in the dimer and the second disulfide bond (Cys341Cys356) anchors a -hairpin at the active site entrance (Hothorn et al., 2006)
It may have the potential to perform many additional functions in the body although currently, research is limited
PMID: 28853742
While our study benefits from robust epidemiological evidence combined with detailed mechanistic validation, we acknowledge certain limitations
