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Growth hormone has potent lipolytic effects on adipose tissue through direct mechanisms independent of IGF-1

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To evaluate the therapeutic efficacy of LXR inverse agonists in vivo, we used three different dysmetabolic rodent models, including high-fat diet (HFD)-induced obese (DIO) mice, HFD-fed Zucker diabetic fatty (ZDF) rats and HFD-fed SpragueDawley (SD) rats (Extended Data Fig