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prepared CS NPs encapsulating daptomycin, proposing them as an ocular delivery system for the antibiotic to treat bacterial endophthalmitis, thereby enhancing local therapeutic effects and avoiding systemic drug toxicity [215]

Prednisolone doses appropriate to rat glucocorticoid excess models

Lin et al

For instance, a landmark study on a human gut-liver-kidney on chip demonstrated the accurate replication of human-specific pharmacokinetics of cisplatin, predicting its dose-dependent nephrotoxicity which is a human-relevant outcome that can be poorly predicted by rodent models (211)

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