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We extracted 51 observations from 11 prospective cohort studies and 4 casecontrol studies across 36 locations (Supplementary Table 3) 6,8,9,10,78,108,109,110,111,112,113,114,115,116

In the current study, we sought to determine whether Nrf2 signaling activated through tobacco smoke exposure could provide a common mechanistic link between altered immunity and reduced effectiveness of chemoradiotherapy through modulation of the oxidative stress response and metabolic adaptation in HNSCC regardless of HPV association

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