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Much of Noopept cognitive effect may be mediated through its metabolite cycloprolylglycine (cPG), which concentrates preferentially in the hippocampus and has been shown to reduce hippocampal cell death, increase BDNF mRNA, and modulate inflammatory cytokine expression

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Although direct human studies on PDA are not yet available, related pentadecapeptide research offers encouraging insights into tissue recovery and regeneration

It represents a precautionary approach given limited long-term data rather than a response to documented concerns