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Perillo et al., ROS in cancer therapy: the bright side of the moon

These findings challenge the traditional natural equals safe paradigm and necessitate evidence-based dosing recommendations

Notably, non-internalized NPs like pristine SiO 2 NPs [452] and LaVO 4 :Eu 3+ NPs [459] can still trigger eryptosis, relying on Ca 2+ signaling, which can be mediated by their direct influence on Piezo1 channels

How much of an oral dose reaches circulation varies between individuals, and IV delivery can produce higher circulating levels than an equivalent oral dose

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