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While initial attempts have achieved partial recapitulation of testicular cell interactions, these models have not yet demonstrated the capacity to support complete spermatogenesis from stem cells to mature sperm (144)

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It is a well-established model for osteoarthritis, especially in cohorts of older age than we used here (52w) (Botter et al., 2011) and for the unhealthy loss in muscle (sarcopenia) and fat mass(Wijnhoven et al., 2005)