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The interaction of melatonin with various isoforms of histone deacetylase (HDAC) alters its activity and can increase or decrease acetylation, favoring in all cases the suppression of proliferation and the induction of cell apoptosis

Desmots F, Rissel M, Gilot D et al (2002) Pro-inflammatory cytokines tumor necrosis factor and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes

The values of basal bEnd.3 cells were used as a baseline and set to a relative protein expression value of 1