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Rats with acute pancreatitis had a 21% reduction in cardiac output, a 37% decrease in contractility, a 23% decline in diastolic tension, and a twofold increase in the cardiac tissue edema index [80]
Notably, Nrf2/HO-1 inhibits the overexpression of the key inflammatory mediator cyclooxygenase-2 (COX-2), resulting in an anti-inflammatory effect
Molecular hydrogen protects human melanocytes from oxidative stress by activating Nrf2 signaling