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Nineteen functional polymorphisms that alter the NFB-mediated inflammatory response ( TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF- signaling ( TNFA (TNF-) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3 (A20) (rs6927172)) and other cytokines regulated by NFB ( IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC ( P 0.05)
Both signaling pathways are key regulators of inflammation and pro-inflammatory responses, which are considered targets for developing anti-inflammatory therapeutic agents [23-26]
This condition, known as pernicious anemia, happens when red blood cells cant mature properly due to lack of B12
(1997) Trends Pharmacol.Sci
