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Ingredients that are on the FDA negative list also cannot be used as active ingredients for human compounding unless a specific route or dose is allowed on the list, as is the case with oral doses of diethylstilbestrol under 25 mg

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Jamal M, Van der Does W, Elzinga BM, Molendijk ML, Penninx BWJH

Published steady-state exposure puts 14 mg oral daily closer to a 0.5 mg weekly injection, and even 25 mg oral daily lands near a 0.9 mg weekly injection short of Wegovy 2.4 mg. Switching routes is an exposure change, not a brand swap

This explains why researchers observe sustained benefits during the off-cycle period