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This phase is followed by the condensation of six isopentenyl pyrophosphate molecules to form squalene, then undergoes cyclization catalyzed by squalene monooxygenase (SM), producing 2,3-oxidosqualene, which is further processed through multiple enzymatic steps to generate cholesterol [25, 28] (Fig

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Early programmes, institutional studies, and preclinical model work examined how the compound class might influence receptor signalling, cellular adaptation, or tissue-level response patterns under controlled conditions

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Gastrointestinal side effects have generally been consistent with those of incretin based therapies