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In initial animal studies, that elucidated the role of glucose metabolism in insulin secretion, the rodent GLUT2 transporter was identified as the major sensor and transporter of glucose in pancreatic -cells

A rapid over-lap PCR method composed of 2-step PCR was used to construct a ZFTF overexpression cassette (Figure 5A)

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Additionally, we evaluated the stability, in vitro GSH-responsive release capability, and inhibitory effects on human lung cancer cells of the FA-CMC-GNA NPs