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At the center of this effort is a molecule often called the master antioxidant: glutathione
These changes can vary among individuals
In the HG/TGF--induced HK-2 and STZ-induced diabetic rat models, the expression of the relevant mitochondrial functional proteins PINK1, Parkin, Fundc1, LC3II, Atg5, MFN2, and MFN1 was significantly reduced, and vitamin D receptor (VDR) agonist treatment increased the expression of the relevant proteins, alleviated the dysfunction of mitophagy, inhibited mitochondrial fission, reduced mitochondrial ROS, and increased the integrity of MAMs, leading to the conclusion that VDR agonists can promote the restoration of mitophagy by regulating the MFN2-MAMs-Fundc1 pathway in renal tubular cells, and thus play a nephroprotective role [138]
Indeed, plasma homocysteine concentration was correlated with plasma fibrinogen in hyperhomocysteinemic patients with coronary heart disease (von Eckardstein et al, 1994)
Evaluations of holey graphene oxide modified ultrafiltration membrane and the performance for water purification
