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[DOI] [PubMed] [Google Scholar] 34.Illum L., Jabbal-Gill I., Hinchcliffe M., Fisher A., Davis S

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In mice with DSS-induced colitis, ginger alleviates the pathological lesions and reduces the expression of IL-6 and iNOS (131)

Together, these modifications reduce IGFBP binding affinity by approximately 100-fold while preserving full agonist activity at the type 1 IGF receptor (IGF-1R), creating a molecule with dramatically enhanced bioavailability in biological systems