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It has been observed to upregulate genes associated with tissue repair and antioxidant defense while downregulating genes linked to inflammation and fibrosis

TB-4: Clinical Data for Unrelated Endpoints Meaningful human trial data for full-length TB-4 (corneal-healing Phase 2/3 as RGN-259, plus cardiac and wound-repair programs) Clean Phase 1 safety Cosmetic dosing is extrapolated from these programs Note: Full-length trial data does not transfer to the TB-500 fragment, so verify vial identity

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using obese murine models suggests that these models may exhibit a downregulation of -adrenergic receptors (-AR)