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To further investigate the role of the dimerized form of PGRMC1 in cancer proliferation, we performed PGRMC1 knockdown-rescue experiments using FLAG-tagged wild-type and Y113F PGRMC1 expression vectors, in which silent mutations were introduced into the nucleotide sequence targeted by shRNA (Fig

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid- uptake in astrocytes

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