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Signal transduction and targeted therapy, 2017, 2(1): 1-9

An increase in the abundance of subgingival bacteria and specific alterations in its composition can lead to damage of periodontal tissues, while the inflammation caused by periodontitis can, in turn, alter the oral subgingival microbiota, creating a vicious cycle (Schtzle et al., 2003)

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Its pathogenicity is closely linked to specific adhesion-associated genes (e.g., fimA, sfaA, and focA) and aminoglycoside-resistance genes (aph(6)-Id, strAB), which facilitate both mucosal colonization and evasion of conventional antimicrobial therapy 134

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