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Phase 2, randomized, placebo-controlled trial of dapirolizumab pegol in patients with moderate-to-severe active systemic lupus erythematosus

The blood-tumor barrier is characterized by higher permeability to small molecules, although a large majority of drug therapies are still unable to penetrate the CNS in adequate concentration because of their large size and transport mechanisms, such as Pgp, that shuttle drug away from the brain

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Importantly, recent research progress has substantially broadened our understanding of the additional physiological functions of erythrocytes