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OCR was significantly blocked, and ATP production, basal respiration, and maximal respiration were significantly decreased after COM treatment compared to that in the control group

Protein S -nitrosylation, the covalent attachment of nitric oxide (NO) moiety to the reactive thiol group of a cysteine residue to form S -nitrosothiol is an important PTM for most classes of proteins ( S -nitrosylated proteins such as Bcl-2, p53, HIF-1, PTEN, and Src are involved in cell survival, angiogenesis, tumorigenesis, and response to cancer treatment (68)

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

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This provides an experimental basis for the application of Fer-1 as a potential therapeutic drug in the clinical treatment of PCOS ( Salvia miltiorrhiza Bunge)