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(2023) 143:55465.e9

However, DHODHs role appears context dependent and debated, suggesting that patient stratification (for example, mitochondrial redox burden, GPX4/FSP1 status and metabolic state) will probably determine where DHODH inhibition provides ferroptosis-relevant benefit

Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

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