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Then this interleukin binds CD8+ NKG2D+ T cells to further stimulate IFN- production through JAK1 and JAK3 pathways, forming a positive feedback loop (Figure 1) that destroys anagen hair follicles and leads to alopecia areata (34)

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Wilsons disease is the paradigmatic example: an inherited defect in the ATP7B copper-transport protein that impairs the bodys ability to remove excess copper, causing toxic copper accumulation in the liver, brain, eyes, and other organs

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