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Injectable protocols may allow longer continuous use due to more predictable blood levels, while oral protocols might benefit from periodic breaks to maintain absorption efficiency

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22 The relationship between NO and phenomena related to the spinal transmission of nociceptive inputs has been generally studied using the effects of NOS inhibitors (NOSIs) on nociception-related electrophysiological responses of dorsal horn cells after formalin

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Most protocols are cyclical, four to eight weeks on, time off, then re-evaluate