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Additional identification of GPx tagSNPs and systematic evaluation of their associations with cancer will help to expand the ability to diagnose and treat GPx1-related cancers

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LOOH are the most abundant primary products [12] and the decomposition of LOOH can generate reactive carbonyl species (RCS), such as short-chain carbonyl derivatives and oxidized truncated phospholipids [35]

The results manifested that shGSTM3 enhanced the expression of HK2, PKM2, and LDHB (crucial enzymes that enhance the glycolysis) and vice versa in the GSTM3-OE group (Figure 7E)