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The glutaredoxin catalytic mechanism depends on the GSH/GSSG ratio

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In addition, due to the inability to effectively detoxify CN, a deficiency of such amino acids has also been postulated to reduce a key antioxidant, glutathione, thereby hindering responses to the cyanide exposure-related oxidative stress, however, direct evidence of this mechanism has been scarce 12,13

[DOI] [PubMed] [Google Scholar] 30.Petrovic I., Dobric I., Drmic D., Sever M., Klicek R., Radic B., Brcic L., Kolenc D., Zlatar M., Kunjko K., et al

The biochemical features of different tags influence the stability, solubility and expression of proteins to which they are attached (Stevens et al