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In Vitro / Preclinical Disclaimer: The research findings described above were observed in laboratory (in vitro) and/or animal model studies

New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition

Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway

These results suggest that GGCT knockdown can significantly inhibit tumor growth and reduce GSH production and that the addition of the ROS inhibitor NAC can significantly rescue this effect

[DOI] [PMC free article] [PubMed] [Google Scholar] Makris EA, Responte DJ, Paschos NK, Hu JC, Athanasiou KA (2014) Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen cross-linking