In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)
While preliminary safety data appears promising, more comprehensive human studies are needed to establish definitive dosing guidelines and safety parameters
Its a marker, not a mechanism
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Well look at its important roles, what happens if you dont have enough, and how injections help keep levels right