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Retrieved from BMJ

The 4-week minimum at each dose level is not arbitrary

STIMULATION OF LIPOLYSIS DURING FASTING Fasting acutely stimulates lipolysis, upregulating the serum concentration of fatty acids and glycerol that act as oxidative substrates to maintain energy requirements for other metabolic tissues

And people love hearing this but there is some research that shows B12 can cause a little boost in energy, especially the first day or two after your shot

I usually notice an uptick in my energy levels a few days after my doc gives the shot." Zoe Macfarlane, 43, Los Angeles Try it: Needles bypass the gut to deliver the nutrient straight to the muscle, so you may feel the effects as soon as the "juice" goes in or up to a few days after