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Growth Hormone & IGF Research , 2014 Showed upregulation of GH receptor expression in tendon fibroblasts, supporting connective tissue repair mechanisms

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This review addresses the interplay between GH, IGF-1, and insulin in type 1 and 2 diabetes mellitus, liver cirrhosis, and acromegaly

For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit