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Free-Fe admixtures that can cause the production of free radicals should be substituted with bound-Fe, such as Fe dextran, for patients who need Fe supplementation in their total parenteral nutrition (TPN) solutions

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In contrast, chronic elevations in TMAO, a metabolite derived from LC, have been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly in older adults with compromised renal function [64, 65]

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