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Discussion PD remains a critical public health challenge due to its progressive neurodegenerative nature and the lack of therapies that halt or reverse its progression

doi: 10.1124/jpet.106.108597 42 LiuYDrozdovIShroffRBeltranLEShanahanCM

25-27 Furthermore, IC/BPS patients displaying widespread pain showed multiple indications of central neurobiological pain sensitization, correlating with quantitative sensory testing, fMRI (functional magnetic resonance imaging), and inflammatory markers

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