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Inside the nucleus, it binds to the ARE in the promoter region of its target genes, driving the expression of cryoprotective proteins such as HO-1, NQO1, and glutathione S-transferase [25]

9 , e0003504 (2015)

Esta revisin de 2018 realizada por Loren Pickart (quien descubri originalmente el GHK-Cu en la dcada de 1970) y Anna Margolina rene dcadas de investigacin y agrega un anlisis de expresin gentica innovador que muestra que el GHK-Cu afecta a casi un tercio de todos los genes humanos

Hydration affects tissue pliability and nutrient delivery

The vertebral fracture risk reduction was numerically superior to teriparatide in a head-to-head comparison arm of the same trial, though the study was not specifically powered for that comparison