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How IGF-1 LR3 Works IGF-1 LR3 functions by binding to the IGF-1 receptor, activating intracellular signaling pathways that promote protein synthesis, muscle fiber hypertrophy, and nutrient uptake

10.1161/JAHA.120.018633 Summary Keywords intracranial aneurysm, DNA methylation, mRNA expression, 5-aza-2'-deoxycytidine, glutathione S-tranferase alpha 4 Citation Xu T, Yu X, Zhou S, Wu Y, Deng X, Wu Y, Wang S, Gao X, Nie S, Zhou C, Sun J and Huang Y (2023) DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner

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Specifically, the accumulated copper ions within cells directly bind to lipoylated proteins in the TCA cycle, leading to their inactivation and subsequent cell death (Fig